Dispersible Tablets Background Many medicines are only available in adult strength; therefore the administration of accurate dosage for children is critical. The taste of the medication is also an important parameter for adherence to treatment and compliance.
Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fast-dissolving tablets. ODT administered without water. A very elderly patient may not be able to swallow a daily dose of antidepressant Advantages: Advantages Improved patient compliance Administration to patients who cannot swallow No need of water for swallowing the dosage forms Accurate dosing as compared to liquids Rapid drug therapy intervention is possible Can be produced at industrial scale more simply and more efficiently.
More rapid drug absorption through pre-gastric absorption from the mouth, pharynx and oesophagus. Disadvantages Drugs absorbed at specific site cannot be given in these dosage forms. Desired Criteria Not require water to swallow, but it should dissolve or disintegrate in the mouth in matter of seconds.
Be portable without fragility concern.
Have a pleasing mouth feel. Leave minimal or no residue in the mouth after oral administration. Exhibit low sensitivity to environmental conditions as humidity and temperature Techniques: Physiology Of Taste Physiology of the tongue Papillae and taste buds: Papillae and taste buds Taste Masking: Taste Masking An ideal taste masking process and formulation should have the following properties - Rapid and easy to manufacture Involves least number of equipment Requires minimum number of excipients for an optimum formulation Has no adverse effect on drug bioavailability Requires excipients that are economical and easily available.
Methods of Taste Masking: Methods of Taste Masking A. Complexation and Adsorption I. Molecular complexes of drug with other chemicals IV Solid dispersion system Slide Formation of Prodrug II.
Coating of drug particles with inert agents III. Mass extrusion method Dispersion coating C. Using Microspheres or Microcapsules Excipients: Excipients Important criteria for excipients - It must be able to disintegrate quickly Their individual properties should not affect the ODTs It should not interfere in the efficacy and organoleptic properties of the product When selecting binder a single or combination of binders care must be taken in the final integrity and stability of the product Selecting the superdisintegrant: Selecting the superdisintegrant Factors for selecting the superdisintegrants Disintegration Compactability Mouth feel Flow Excipients: Superdisintegrants Crosspovidone Microcrystalline cellulose Sodium starch glycollate Sodium carboxy methyl cellulose Pregelatinised starch Calcium carboxy methyl cellulose Modified corn starch.
Evaluation of formulated tablets: Evaluation of taste masking A. Paired Difference Test b. Triangle Difference Test c. Duo-Trio Test Slide Single Attribute Test d. This ODT can be used easily in children who have lost their primary teeth and in geriatric patients who have lost their teeth permanently which made them popular.
Thus ODT may be developed for most of the available drugs in near future. The Theory and Practice of Industrial Pharmacy. Varghese publishing house; Mumbai. A review of the literature, Indian Journal of Pharmaceutical Science.Preparation of orodispersible tablets of chlorzoxazone.
Fifteen ODT formulations of CLZ were prepared by direct compression method as shown in Table regardbouddhiste.com drug and the directly compressible excipients were mixed by adding small portion of each at a time and blended to get a uniform mixture.
Orodispersible tablets (ODTs). Usually, elderly people experience difficulty in swallowing the conventional dosage forms like tablets, capsules, solutions and suspensions . term orodispersible tablet for a tablet that disperses or disintegrates in less than 3 minutes in the mouth before swallowing.
Such a tablet disintegrates into smaller tablets and disintegration of associated particles into individual components for fast dissolution.
Th is requires that excipients should have high wettability, and the tablet. The tablets were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, disintegration time (DT) and dissolution study.
Using the same excipients, the tablets were prepared by direct compression and were evaluated in the similar way. Drug content. Orally Disintegrating Tablets Thesis Paper – This of orally disintegrating tablets in a Nomenclature Ultima in our database or order an original thesis paper that will be Orodispersible Tablets Thesis regardbouddhiste.com Estudo Geral Master thesis in Pharmaceutical Orally Disintegrating Tablets Thesis Writing Orally Disintegrating.
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